Dr. Afonso Duarte

Cellular Protein Chemistry O707 Department of Chemistry Faculty of Science Utrecht University Padualaan 8 NL-3584 CH Utrecht The Netherlands T   +31 30 253 4105 F   +31 30 253 6900 E   a.m.dossantosduarte @ uu.nl Webpage

Research Interest

Structural properties of chaperones

Publications

Afonso M.S. Duarte, Edwin R. de Jong, Rob B. M. Koehorst and Marcus A. Hemminga, Conformational studies of peptides representing a segment of TM7 from V_O-H⁺-V-ATPase in SDS micelles, Eur. Biophys. J. (2010), in press.

Afonso M.S. Duarte and Marcus A. Hemminga, "Tracking down a new putative drug target for osteoporosis: Structure of an essential region of the proton translocation channel of H+-VO-ATPase", in Antibiotic Resistance: Causes and Risk Factors, Mechanisms and Alternatives, Columbus, F., Ed., Nova Science Publishers, Hauppauge, New York, USA (2009);

Afonso M. S. Duarte, Carlo P. M. van Mierlo, Marcus A. Hemminga “Molecular dynamics study of the solvation of an α-helical transmembrane peptide by DMSO”, Journal of Physical Chemistry B, 2008 112 (29), 8664-8671;

Afonso M.S. Duarte, Cor J. A. M. Wolfs, Rob B. M. Koehorst, Jean-Luc Popot, Marcus A. Hemminga “Solubilization of V‑ATPase transmembrane peptides by amphipol A8‑35”, Journal of peptide science 14, 2008, 389-393;

Afonso M. S. Duarte, Edwin R. de Jong, Rainer Wechselberger, Carlo P. M. van Mierlo, Marcus A. Hemminga “Segment TM7 from the cytoplasmic hemi-channel from VO-H+-V-ATPase includes a flexible region that has a potential role in proton translocation”, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768, 9, 2007, 2263-2270;

Afonso M. S. Duarte, Cor J. A. M. Wolfs, Nico A. J. van Nuland, Michael A. Harrison, John B. C. Findlay, Carlo P. M. van Mierlo, Marcus A. Hemminga “Structure and localization of an essential transmembrane segment of the proton translocation channel of yeast H+-V-ATPase”  Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768, 2, 2007, 218-227.