Research Articles - Ineke Braakman

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1. Hanneke Hoelen, Bertrand Kleizen, Andre Schmidt, John Richardson, Paraskevi Charitou, Philip J. Thomas, Ineke Braakman. The Primary Folding Defect and Rescue of ΔF508 CFTR Emerge during Translation of the Mutant Domain. PLoS ONE, 5, 11, 2010 doi:10.1371/journal.pone.0015458
2. van der Zand A, Braakman I, Tabak HF. Peroxisomal membrane proteins insert into the endoplasmic reticulum. Mol Biol Cell. 2010 Jun 15;21(12):2057-65
3. Christis C, Fullaondo A, Schildknegt D, Mkrtchian S, Heck AJ, Braakman I. J. Regulated increase in folding capacity prevents unfolded protein stress in the ER. Cell Sci. 2010 Mar 1;123(Pt 5):787-94.
4. Pena F, Jansens A, van Zadelhoff G, Braakman I. Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum. J Biol Chem. 2010 Mar 19;285(12):8656-64.
5. van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I. Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17019-24.
6. Braakman I. Entering a new era with Ero. Nat Rev Mol Cell Biol. 2009 Aug;10(8):503.
7. Bontjer I, Land A, Eggink D, Verkade E, Tuin K, Baldwin C, Pollakis G, Paxton WA, Braakman I, Berkhout B, Sanders RW. Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution. J Virol. 2009 Jan;83(1):368-83. Epub 2008 Oct 15.
8. Sanders, R.W., S.-T. Hsu, E. van Anken, I.M. Liscaljet, M. Dankers, I. Bontjer, A. Land, I. Braakman, A.M. Bonvin & B. Berkhout Evolution rescues folding of HIV-1 Envelope glycoprotein gp120 lacking a conserved disulfide bond. Mol. Biol. Cell (2008) 19 (11): 4707-4716. pdf
   
9. Van Anken, E., R.W. Sanders, I.M. Liscaljet, A. Land, I. Bontjer, S. Tillemans, A.A. Nabatov, W.A. Paxton, B. Berkhout & I. Braakman Only five of 10 strictly conserved disulfide bonds are essential for folding and eight for function of the HIV-1 envelope glycoprotein. Mol. Biol. Cell (2008) 19 (10): 4298-4309. pdf
10. Sanders, R.W., E. Van Anken, A.A. Nabatov, I.M. Liscaljet, I. Bontjer, D. Eggink, M. Melchers, E. Busser, M.M. Dankers, F. Groot, I. Braakman, B. Berkhout & W.A. Paxton. The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion. Retrovirology (2008) 5 (1): 10-24. pdf
11. Piersma D ,Berns EM ,Verhoef-Post M ,Uitterlinden AG ,Braakman I ,Pols HA ,Themmen AP A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients. J. Clin. Endocrinol. Metab. 2006; 91(4): 1470-6. pdf
12. Kleizen B, van Vlijmen T, de Jonge HR, Braakman I Folding of CFTR is predominantly cotranslational. Mol Cell. 2005; 20(2): 277-87. pdf
13. Hoepfner D, Schildknegt D, Braakman I, Philippsen P, Tabak HF Contribution of the ER to perxisome formation. Cell 2005; 122: 85-95. pdf
14. Romijn EP, Christis C, Wieffer M, Gouw JW, Fullaondo A, van der Sluijs P, Braakman I, Heck AJ. Expression clustering reveals detailed co-expression patterns of functionally related proteins during B cell differentiation: a proteomic study using a combination of one-dimensional gel electrophoresis, LC-MS/MS, and stable isotope labeling by amino acids in cell culture (SILAC).
    Mol Cell Proteomics. 2005 ;4(9): 1297-310. pdf
15. Maggioni MC, Liscaljet IM, Braakman I A critical step in the folding of influenza virus HA, determined with a novel folding assay. Nat. Struc. Mol. Biol. 2005, 12: 258-263. pdf
16. Land A, Zonneveld D & Braakman I Folding of HIV-1 envelope glycoprotein involves extensive isomerization of disulfide bonds and conformation-dependent leader peptide cleavage. FASEB J. 2003; 17:1058-67. pdf
17. van Anken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R, Braakman I & Heck AJ Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 2003;18:243-53. pdf supplementary data
18. Jansens A, van Duijn E & Braakman I Coordinated nonvectorial folding in a newly synthesized multidomain protein. Science 2002;298:2401-3. full text pdf supplementary data
19. Mezghrani A, Fassio A, Benham A, Simmen T, Braakman I & Sitia R Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J. 2001; 15:6288-96. pdf
20. Benham AM, Cabibbo A, Fassio A, Bulleid N, Sitia R & Braakman I The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha. EMBO J. 2000;19:4493-502. pdf
21. Ermonval M, Duvet S, Zonneveld D, Cacan R, Buttin G & Braakman I Truncated N-glycans affect protein folding in the ER of CHO-derived mutant cell lines without preventing calnexin binding. Glycobiology 2000;10:77-87. pdf
22. Das AT, Land A, Braakman I, Klaver B & Berkhout B HIV-1 evolves into a nonsyncytium-inducing virus upon prolonged culture in vitro. Virology 1999;10:55-69. pdf
23. Hettema EH, Ruigrok CC, Koerkamp MG, van den Berg M, Tabak HF, Distel B & Braakman I The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import. J Cell Biol. 1998;142:421-34. pdf
24. van Weering DH, Moen TC, Braakman I, Baas PD & Bos JL Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium. J Biol Chem. 1998;273:12077-81. pdf
25. Zhang JX, Braakman I, Matlack KE & Helenius A Quality control in the secretory pathway: the role of calreticulin, calnexin and BiP in the retention of glycoproteins with C-terminal truncations. Mol Biol Cell. 1997;8:1943-54. pdf
26. Chen W, Helenius J, Braakman I & Helenius A Cotranslational folding and calnexin binding during glycoprotein synthesis. Proc Natl Acad Sci U S A 1995;92:6229-33. pdf
27. Hammond C, Braakman I & Helenius A Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proc Natl Acad Sci U S A 1994;91:913-7. pdf
28. Tatu U, Braakman I & Helenius A Membrane glycoprotein folding, oligomerization and intracellular transport: effects of dithiothreitol in living cells. EMBO J. 1993;12:2151-7. pdf
29. de Silva A, Braakman I & Helenius A Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes. J Cell Biol. 1993;120:647-55. pdf
30. Braakman I, Helenius J & Helenius A Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum. EMBO J. 1992;11:1717-22. pdf
31. Braakman I, Helenius J & Helenius A Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum. Nature 1992;356:260-2. pdf
32. Braakman I, Hoover-Litty H, Wagner KR & Helenius A Folding of influenza hemagglutinin in the endoplasmic reticulum. J Cell Biol. 1991;114:401-11. pdf

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