Research Topics

Braakman group

• Folding of model proteins in the endoplasmic reticulum of intact cells.
  - Influenza Hemagglutinin (HA)
  - HIV Envelope
  - LDL receptor
  - CFTR
• The role of molecular chaperones and folding enzymes in protein folding and production.
  - Calnexin/calreticulin
  - Ero1 & PDI
  - Novel ER folding factors
• ER expansion and ER stress.
  - ER expansion during B cell differentiation
  - Effects of ER stress on the proteome of mammalian cells

Rüdiger group

• Molecular mechanisms of chaperone interaction with their substrates.
  - Substrate recognition of molecular chaperones
  - Mechanisms of chaperone-assisted protein folding
  - Structural properties of chaperone substrates

Tabak group

• Formation and maintenance of Peroxisomes and peroxisomal protein import.
  - Peroxisome biogenesis & the ER connection
  - Peroxisome partitioning
  - The role of molecular chaperones in peroxisomal protein import