Ing. Guus van Zadelhoff

Cellular Protein Chemistry  O 707  Department of Chemistry  Faculty of Science  Utrecht University  Padualaan 8  NL-3584 CH Utrecht  The Netherlands  T +31 30 253 4105  F +31 30 254 0980  E g.vanzadelhoff@uu.nl

Research Topic

Folding of Influenza Hemagglutinin (HA)

Curriculum Vitae

Education & Courses

1991        Cursus ANuclear Magnetic Resonance@  aan de Universiteit Utrecht.
1993        Cursus AMass Spectroscopy@ aan de Universiteit Utrecht.
1995-heden    Lid dagelijks bestuur sectie Bio-organische chemie.
1995-1996    Opleiding AStralingsdeskundige niveau-3" (Universiteit Leiden).
1996-2000     Stralingsdeskundige isotopenlaboratoria sectie Bio-organische chemie
1996-heden    Arbo & Milieu contactpersoon sectie Bio-organische chemie.
1996        Cursus Awriting english for publication@ (Universiteit Utrecht).
1997         Basiscursus AVeiligheid en milieu in laboratoria@. (Universiteit Utrecht).
 1998         Vervolgcursus AVeiligheid en milieu in laboratoria@ (Universiteit Utrecht).
2000-heden    Stralingsdeskundige isotopenlaboratoria sectie Cellulaire eiwit chemie.
2001        Opfriscursus AStralingsdeskundige niveau-3" (Universiteit Utrecht).

Publications

Wadman, M.W.; van Zadelhoff, G.; Hamberg, M.; Visser, T.; Veldink, G.A.; Vliegenthart, J.F.G. Conversion of linoleic acid into novel oxylipins by the mushroom Agaricus bisporus. Lipids (2005), 40(11), 1163-1170.

Dainese, E.; Sabatucci, A.; van Zadelhoff, G.; Angelucci, C.B.; Vachette, P.; Veldink, G.A.; Finazzi-Agro, A.;Maccarrone, M.   Structural stability of soybean lipoxygenase-1 in solution as probed by small angle X-ray scattering. Journal of Molecular Biology (2005), 349(1), 143-152.

Maccarrone, M.; Di Venere, A..; van Zadelhoff, G.; Mei, G.; Veldink, G.A.; Rosato, N.; Finazzi-Agro, A.  Futher structural and functional properties of mini-lipoxygenase, an active fragment of soybean lipoxygenase-1. Spectroscopy (2004), 18(2), 331-338.

Veldhuis, W. B.; van der Stelt, M.; Wadman, M. W.; van Zadelhoff, G.; Maccarrone, M.; Fezza, F.; Veldink, G. A.; Vliegenthart, J. F. G.; Bar, P. R.; Nicolay, K.; Di Marzo, V.  Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: Role of vanilloid receptors and lipoxygenases. Journal of Neuroscience (2003),  23(10),  4127-4133.

Di Venere, A.; Salucci, M. L.; van Zadelhoff, G.; Veldink, G.; Mei, G.; Rosato, N.; Finazzi-Agro, A.; Maccarrone, M.  Structure-to-Function Relationship of Mini-Lipoxygenase, a 60-kDa Fragment of Soybean Lipoxygenase-1 with Lower Stability but Higher Enzymatic Activity. Journal of Biological Chemistry  (2003),  278(20),  18281-18288.

Van Der Stelt M.; Veldhuis W.B.; Wadman M.W.; Van Zadelhoff G.; Fezza F.; Veldink G.A.; Vliegenthart J.F.G.; Bar P.R.; Nicolay K.; Di Marzo V.  Mechanisms underlying in vivo neuroprotection by the endocannabinoid anandamide and the cannabinoid/vanilloid receptor agonist, arvanil. Journal of Neurochemistry  (2003),  85 Suppl 2.6.

van der Stelt, M.; van Kuik, J.A.; Bari, M.; van Zadelhoff, G.; Leeflang, B.R..; Veldink, G.A.; Finazzi-Agro, A.; Vliegenthart, J.F.G..; Maccarrone, M.  Oxygenated Metabolites of Anandamide and 2-Arachidonoylglycerol: Conformational Analysis and Interaction with Cannabinoid Receptors, Membrane Transporter, and Fatty Acid Amide Hydrolase. Journal of Medicinal Chemistry  (2002),  45(17),  3709-3720.

Maccarrone, M.; Salucci, M.L.; van Zadelhoff, G.; Malatesta, F.; Veldink, G.A.; Vliegenthart, J.F.G.; Finazzi-Agro, A.  Tryptic digestion of soybean lipoxygenase-1 generates a 60 kDa fragment with improved activity and membrane binding ability. Biochemistry  (2001),  40(23),  6819-6827. 

Maccarrone, M.; Van Zadelhoff, G.; Veldink, G.A.; Vliegenthart, J.F.G.; Finazzi-Agro, A.  Early activation of lipoxygenase in lentil (Lens culinaris) root protoplasts by oxidative stress induces programmed cell death. European Journal of Biochemistry  (2000),  267(16),  5078-5084.

Van der Stelt, M.; Noordermeer, M.A.; Kiss, T.; Van Zadelhoff, G.; Merghart, B.; Veldink, G.A.; Vliegenthart, J.F.G.  Formation of a new class of oxylipins from N-acyl(ethanol)amines by the lipoxygenase pathway. European Journal of Biochemistry  (2000),  267(7),  2000-2007.

Van Zadelhoff, G.; Veldink, G.A.; Vliegenthart, J.F.G.  With anandamide as substrate plant 5-lipoxygenases behave like 11-lipoxygenases. Biochemical and Biophysical Research Communications  (1998),  248(1),  33-38.

Hard, K.; Van Zadelhoff, G.; Moonen, P.; Kamerling, J.P.; Vliegenthart, J.F.G.  The Asn-linked carbohydrate chains of human Tamm-Horsfall glycoprotein of one male.  Novel sulfated and novel N-acetylgalactosamine-containing N-linked carbohydrate chains. European Journal of Biochemistry  (1992),  209(3),  895-915.