Seminar by Prof. Patrick Cramer

Prof. Patrick Cramer, (director) Gene Center Munich, Germany

30^th November 2006,

16.00 Auditorium Hubrecht Lab.,

Utrecht Graduate School of Developmental Biology seminar series.

“Structure function of eukaryotic transcription machinery”

Abstract

No abstract is available as yet, but the following may be of interest:

In 2001, Patrick Cramer finished his post-doc with the landmark 2.8 A structure of RNA Polymerase II. He has continued working on the structure of pivotal components of the eukaryotic transcription machinery at the Gene Center in Munich, of which he is now director. A few recent publications are listed below. Patrick Cramer gives excellent seminars, with a focus on elucidating transcription regulation through studies of structure, combined with elegant biochemistry and molecular biology.

Relevant publications

• Kettenberger H, Eisenfuhr A, Brueckner F, Theis M, Famulok M, Cramer P., Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs., Nat Struct Mol Biol. 2006 Jan;13(1):44-8.
• Kettenberger H, Armache KJ, Cramer P.,Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS., Mol Cell. 2004 Dec 22;16(6):955-65.
• Meinhart A, Cramer P., Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors., Nature. 2004 Jul 8;430(6996):223-6.
• Kettenberger H, Armache KJ, Cramer P., Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage., Cell. 2003 Aug 8;114(3):347-57.
• Cramer P, Bushnell DA, Kornberg RD., Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution., Science. 2001 Jun 8;292(5523):1863-76.